With an unleashed US president seemingly determined to destroy tried and trusted transatlantic ties along with the multilateral order that the United States created together with its Western European allies after WWII, the European Union finds itself more and more on its own. The EU has to (re)define what role it wants to play in a global context and in its neighbourhood. In light of the loss of important military and soft power through Brexit and the ongoing internal crisis characterised by Euroscepticism and right-wing populism, this prospect is uninviting, but urgency and necessity are obvious.  In this web dossier, we will focus on three topics: the Western Balkans enlargement strategy; the conflicts in the Middle East (Jerusalem, Syria), the refugee crisis and the transatlantic tug-of-war. ​